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No particular dose adjustment advised when tofacitinib coadministered with powerful CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with the two reasonable CYP3A4 and strong CYP2C19 inhibitors .modafinil will minimize the extent or influence of fruquintinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or